Invention Grant
- Patent Title: Methods of intracellular conversion of single-chain proteins into their di-chain form
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Application No.: US15155302Application Date: 2016-05-16
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Publication No.: US09938514B2Publication Date: 2018-04-10
- Inventor: Sanjiv Ghanshani , Linh Q. Le , Yi Liu , Lance E. Steward
- Applicant: Allergan, Inc.
- Applicant Address: US CA Irvine
- Assignee: Allergan, Inc.
- Current Assignee: Allergan, Inc.
- Current Assignee Address: US CA Irvine
- Agent Brigitte C. Phan; Ted A. Chan
- Main IPC: C12P21/04
- IPC: C12P21/04 ; C12N9/52 ; C07K14/33 ; C12N9/50 ; C12N15/70 ; C12P21/00 ; C12P21/06
Abstract:
The present specification discloses expression constructs comprising single-chain proteins comprising a di-chain loop region comprising an exogenous protease cleavage site and a protease that can cleave the exogenous protease cleavage site located within the di-chain loop, cell compositions comprising such expression construct, and intracellular methods of converting the single-chain protein into its di-chain form.
Public/Granted literature
- US20160319265A1 Methods Of Intracellular Conversion Of Single-Chain Proteins Into Their Di-Chain Form Public/Granted day:2016-11-03
Information query
