Invention Grant
- Patent Title: Non-natural amino acid tRNA synthetases for para-methylazido-L-phenylalanine
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Application No.: US15028396Application Date: 2014-10-10
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Publication No.: US09938516B2Publication Date: 2018-04-10
- Inventor: Erik S. Zimmerman , Christopher Thanos
- Applicant: SUTRO BIOPHARMA, INC.
- Applicant Address: US CA South San Francisco
- Assignee: SUTRO BIOPHARMA, INC.
- Current Assignee: SUTRO BIOPHARMA, INC.
- Current Assignee Address: US CA South San Francisco
- Agency: Kilpatrick Townsend & Stockton LLP
- International Application: PCT/US2014/060058 WO 20141010
- International Announcement: WO2015/054587 WO 20150416
- Main IPC: C12N9/00
- IPC: C12N9/00 ; C07K1/02 ; C12P21/02 ; A61K31/40 ; A61K47/48 ; C07K16/32

Abstract:
The invention provides methods and compositions for a mutein aminoacyl-tRNA synthetase that preferentially charges a tRNA with a non-natural amino acid. Also provided are methods for incorporating the non-natural amino acid, para-methylazido-L-phenylalanine into a protein and further conjugating a biologically active adduct to the para-methylazido-L-phenylalanine.
Public/Granted literature
- US20160257946A1 NON-NATURAL AMINO ACID tRNA SYNTHETASES FOR PARA-METHYLAZIDO-L-PHENYLALANINE Public/Granted day:2016-09-08
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