Invention Grant
- Patent Title: Double-stranded and single-stranded RNA molecules with 5′ triphosphates and their use for inducing interferon
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Application No.: US15255942Application Date: 2016-09-02
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Publication No.: US09938529B2Publication Date: 2018-04-10
- Inventor: John J. Rossi , Dongho Kim , Patric Lundberg , Edouard Cantin
- Applicant: CITY OF HOPE
- Applicant Address: US CA Duarte
- Assignee: City of Hope
- Current Assignee: City of Hope
- Current Assignee Address: US CA Duarte
- Agency: Rothwell, Figg, Ernst & Manbeck, P.C.
- Main IPC: C12N15/113
- IPC: C12N15/113 ; A61K31/713 ; C12N15/11 ; C12N15/117
Abstract:
Double-stranded and single-stranded RNA molecules, and their use in methods for inducing interferon are provided. The interferon induction provides anti-viral and other medically useful effects, such as anti-cancer effects. Also provided are methods for reducing or inhibiting interferon induction exhibited by such molecules, particularly siRNA and shRNA molecules produced in vitro.
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