Invention Grant
- Patent Title: Gene vector for inducing transgene-specific immune tolerance
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Application No.: US13128761Application Date: 2009-11-11
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Publication No.: US09938540B2Publication Date: 2018-04-10
- Inventor: Andrea Annoni , Alessio Cantore , Luigi Naldini , Maria Grazia Roncarolo
- Applicant: Andrea Annoni , Alessio Cantore , Luigi Naldini , Maria Grazia Roncarolo
- Applicant Address: IT Milan IT Rome
- Assignee: Ospedale San Raffaele S.r.l.,Fondazione Telethon
- Current Assignee: Ospedale San Raffaele S.r.l.,Fondazione Telethon
- Current Assignee Address: IT Milan IT Rome
- Agency: Steptoe & Johnson LLP
- International Application: PCT/IB2009/007530 WO 20091111
- International Announcement: WO2010/055413 WO 20100520
- Main IPC: A61K39/00
- IPC: A61K39/00 ; C07H21/04 ; C12N5/10 ; C12N15/63 ; C12N15/86 ; C12N15/11
Abstract:
A gene vector adapted for transient expression of a transgene in a peripheral organ cell comprising a regulatory sequence operably linked to a transgene wherein the regulatory sequence prevents or reduces expression of said transgene in hematopoietic lineage cells.
Public/Granted literature
- US20110218234A1 GENE VECTOR FOR INDUCING TRANSGENE-SPECIFIC IMMUNE TOLERANCE Public/Granted day:2011-09-08
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