Systems and methods are provided for machining dental prostheses including, over a network, receiving data concerning a dental prosthesis, selecting a material from which to machine the dental prosthesis, and determining machining instructions for machining the dental prosthesis based on a nominal enlargement factor corresponding to the selected material. The method can also include storing the machining instructions, receiving a request from a milling machine for a dental prosthesis to be milled by the milling machine, and associating the dental prosthesis with the milling machine. The method can also include selecting a material blank comprised of the selected material, determining a material blank enlargement factor of the selected material blank, modifying the machining instructions according to a difference between the nominal enlargement factor and the material blank enlargement factor, and machining the dental prosthesis according to the modified machining instructions.