Invention Grant
- Patent Title: Long poly(A) plasmids and methods for introduction of long poly(A) sequences into the plasmid
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Application No.: US14879023Application Date: 2015-10-08
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Publication No.: US09943612B2Publication Date: 2018-04-17
- Inventor: Andrew M. Scharenberg , Kyle Jacoby , Alexandra E. Grier
- Applicant: Seattle Children's Hospital
- Applicant Address: US WA Seattle
- Assignee: Seattle Children's Hospital
- Current Assignee: Seattle Children's Hospital
- Current Assignee Address: US WA Seattle
- Agency: Knobbe Martens Olson & Bear LLP
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K41/00 ; C12P19/34 ; C12N15/63 ; C12N15/67
Abstract:
Disclosed herein are polynucleotides having a plurality of thymine nucleotides and an endonuclease recognition site inserted therein, methods of engineering the polynucleotides having a plurality of thymine nucleotides and an endonuclease recognition site inserted therein, and methods of enhancing transcription, translation, and increasing stability of a polynucleotide.
Public/Granted literature
- US20160243258A1 LONG POLY(A) PLASMIDS AND METHODS FOR INTRODUCTION OF LONG POLY(A) SEQUENCES INTO THE PLASMID Public/Granted day:2016-08-25
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