- Patent Title: Substituted amino triazoles useful as human chitinase inhibitors
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Application No.: US15255226Application Date: 2016-09-02
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Publication No.: US09944624B2Publication Date: 2018-04-17
- Inventor: Marzena Mazur , Robert Koralewski , Bartlomiej Borek , Sylwia Olejniczak , Wojciech J. Czestkowski , Michał C. Piotrowicz , Jacek P. Olczak , Adam A. Golebiowski , Agnieszka Bartoszewicz , Elżbieta Maziarz , Michał Łukasz Kowalski
- Applicant: OncoArendi Therapeutics S.A.
- Applicant Address: PL Warsaw
- Assignee: OncoArendi Therapeutics S.A.
- Current Assignee: OncoArendi Therapeutics S.A.
- Current Assignee Address: PL Warsaw
- Agency: Foley Hoag LLP
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D413/14 ; C07D417/14 ; C07D498/04
Abstract:
Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.
Public/Granted literature
- US20170066743A1 SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS Public/Granted day:2017-03-09
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