Invention Grant
- Patent Title: Fumarate-CO-releasing molecule hybrids, their use in the treatment of inflammatory or cardiovascular diseases and their process of preparation
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Application No.: US15127674Application Date: 2015-03-20
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Publication No.: US09944669B2Publication Date: 2018-04-17
- Inventor: Roberto Motterlini , Roberta Foresti , Thierry Martens , Michael Rivard
- Applicant: UNIVERSITE PARIS EST CRETEIL VAL DE MARNE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
- Applicant Address: FR Creteil FR Paris FR Paris
- Assignee: UNIVERSITE PARIS EST CRETEIL VAL DE MARNE,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS),INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
- Current Assignee: UNIVERSITE PARIS EST CRETEIL VAL DE MARNE,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS),INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
- Current Assignee Address: FR Creteil FR Paris FR Paris
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: EP14305408 20140321
- International Application: PCT/EP2015/056024 WO 20150320
- International Announcement: WO2015/140337 WO 20150924
- Main IPC: C07F15/06
- IPC: C07F15/06 ; C07F15/00 ; C07F13/00
Abstract:
The present invention relates to hybrid fumarate-CO-releasing molecules capable of increasing heme oxygenase-1 (HO-1) activity and HO-1 protein expression and simultaneously releasing CO, their synthesis and their use in therapeutic applications, in particular their use in the treatment of inflammatory or cardiovascular diseases.
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