A method for data deduplication during execution of an application on a plurality of computing nodes, including: generating, by a first processor in a first computing node executing the application, a first message to process application data owned by a second computing node executing the application; receiving, by a first network interface (NI) of the first computing node, the first message; extracting, by the first NI, a first key from the first message; determining, by the first NI, the first key is not a duplicate; and placing, by the first NI and in response to the first key not being a duplicate, the first message on a network connecting the first computing node to the second computing node.