A memory manager reduces the impact of memory clean-up operations on server performance. The memory manager monitors local memory usage and other resource usage by the server, such as processor, storage, and network usage. When moderately high memory usage is detected, the memory manager performs memory clean-up operations during relatively low processor, storage, and network usage to reduce the impact of the clean-up operations on server performance. When excessively high memory usage is detected, the memory manager more aggressively cleans-up local memory independently of processor, storage, and network usage.