The present invention discloses a three-layer three-zone memory foam mattress, comprising a mattress main body, wherein the mattress main body is composed of a top layer mattress body, a middle layer mattress body and a base layer mattress body, which are sequentially arranged from top to bottom, and a mattress cover is arranged on the surface of the mattress main body; and the middle layer mattress body is composed of a head mattress body, a waist and hip mattress body and a foot mattress body. The mattress is divided into three layers, the first layer is made of the colored gel memory foam, the second layer divides the high-density foam into three zones, the first and third zone adopt the retarding foam, while the second zone adopts the reinforced resilient foam, and the third layer is made of the physical solid-state reinforced foam. The colored gel memory foam can keep the consistency of body contact temperature to create a comfortable sleep environment, the surface and the bottom are made of foam with different hardness to create a sleep effect with one soft surface and one hard surface so as to satisfy the requirements of people at different ages for the hardness of the mattress, and the mattress ensures better fitting of the body and the mattress by means of the special hardness plasticity of the foam products.