The present invention features an anti-rotation instrument system which could be used in all health professions including medical, dental, and any other specialties. The system includes an anti-rotation instrument device featuring a main handle, a first removable hand grip and a first instrumental tip. The first removable hand grip is attached to a first female screw cavity located on the main handle. One end of the instrumental tip passes through a channel located within first hand grip with an anti-rotation key located on the instrumental tip securely residing within a dent located on a distal end of the first removable hand grip having threading located on an end of the instrumental tip that is subsequently screwed into a first female screw cavity of the main handle such that the first hand grip is tightly sandwiched between the first instrumental tip and main body.