Invention Grant
- Patent Title: Inhibitors of beta-secretase
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Application No.: US15383287Application Date: 2016-12-19
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Publication No.: US09949975B2Publication Date: 2018-04-24
- Inventor: Yuri Bukhtiyarov , Salvacion Cacatian , Lawrence Wayne Dillard , Cornelia Dorner-Ciossek , Klaus Fuchs , Lanqi Jia , Deepak S. Lala , Angel Morales-Ramos , Jonathan Reeves , Suresh B. Singh , Shankar Venkatraman , Zhenrong Xu , Jing Yuan , Yi Zhao , Yajun Zheng , Georg Rast
- Applicant: Vitae Pharmaceuticals, Inc.
- Applicant Address: US NJ Madison
- Assignee: Vitae Pharmaceuticals, Inc.
- Current Assignee: Vitae Pharmaceuticals, Inc.
- Current Assignee Address: US NJ Madison
- Agent Andrew C. Chien; Barbara C. Potts
- Main IPC: C07D405/06
- IPC: C07D405/06 ; A61K31/506 ; C07D235/02 ; C07D403/06 ; C07D407/06 ; C07C49/697 ; C07C49/747 ; C07C49/755 ; C07C229/50 ; C07C255/47 ; C07C313/06 ; C07C331/14 ; A61K31/4184
Abstract:
The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.
Public/Granted literature
- US20170196867A1 INHIBITORS OF BETA-SECRETASE Public/Granted day:2017-07-13
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