Invention Grant
- Patent Title: Biochemically stabilized HIV-1 Env trimer vaccine
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Application No.: US15596312Application Date: 2017-05-16
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Publication No.: US09950060B2Publication Date: 2018-04-24
- Inventor: Stephen C. Harrison , Bing Chen , Dan H. Barouch , Joseph P. Nkoloa , Michael Scott Seaman
- Applicant: Beth Israel Deaconess Medical Center , Children's Medical Center Corporation
- Applicant Address: US MA Boston US MA Boston
- Assignee: Beth Israel Deaconess Medical Center,Children's Medical Center Corporation
- Current Assignee: Beth Israel Deaconess Medical Center,Children's Medical Center Corporation
- Current Assignee Address: US MA Boston US MA Boston
- Agency: Panitch Schwarze Belisario & Nadel LLP
- Main IPC: A61K39/00
- IPC: A61K39/00 ; G01N33/569 ; C07K14/29 ; A61K39/02 ; C07K16/12 ; A61K39/21 ; C07K14/005 ; C12N7/00
Abstract:
Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.
Public/Granted literature
- US20170290907A1 BIOCHEMICALLY STABILIZED HIV-1 ENV TRIMER VACCINE Public/Granted day:2017-10-12
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