Invention Grant
- Patent Title: Tertiary amines for use in the treatment of cardiac disorders
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Application No.: US15380613Application Date: 2016-12-15
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Publication No.: US09951033B2Publication Date: 2018-04-24
- Inventor: Kjetil Tasken , Birgitte Lygren , Ellen Ostensen , Jo Klaveness
- Applicant: Universitetet I Oslo
- Applicant Address: NO Blindern
- Assignee: UNIVERSITETET I OSLO
- Current Assignee: UNIVERSITETET I OSLO
- Current Assignee Address: NO Blindern
- Agency: Dorsey & Whitney LLP
- Priority: GB1208775.5 20120518
- Main IPC: C07D307/81
- IPC: C07D307/81 ; C07D213/36 ; C07C211/43 ; C07D277/28 ; C07C217/58 ; C07C229/38 ; C07C211/49 ; C07D257/04 ; C07C211/27 ; C07C275/40
Abstract:
The present invention relates to tertiary amines of formula (I) for use in therapy, particularly for use in treating cardiovascular disorders. The compounds have been found to regulate phospholamban phosphorylation by interfering with the A-kinase anchor protein 18delta (AKAP18δ) binding to the PKA substrate phospholamban. The compounds share a tri(alkylaryl/alkylheteroaryl) amine structure.
Public/Granted literature
- US20170158657A1 TERTIARY AMINES FOR USE IN THE TREATMENT OF CARDIAC DISORDERS Public/Granted day:2017-06-08
Information query
