Invention Grant
- Patent Title: Dihydropyridone P1 as factor XIa inhibitors
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Application No.: US15205059Application Date: 2016-07-08
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Publication No.: US09951071B2Publication Date: 2018-04-24
- Inventor: Wu Yang , James R. Corte , Paul J. Gilligan , Donald J. P. Pinto , William R. Ewing , Andrew K. Dilger , Yufeng Wang , Tianan Fang , Kumar B. Pabbisetty , Leon M. Smith, II
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Hong Liu
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D471/08 ; C07D471/18 ; C07D487/08 ; C07D401/04 ; C07D487/18 ; C07H17/02 ; C07C53/18

Abstract:
The present invention provides compounds of Formula (V): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
Public/Granted literature
- US20160340360A1 DIHYDROPYRIDONE P1 AS FACTOR XIA INHIBITORS Public/Granted day:2016-11-24
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