Invention Grant
- Patent Title: Recombinant fusion protein comprising HIV gp120 linked to an enhancing CD4 binding site mAb
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Application No.: US14649565Application Date: 2013-12-04
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Publication No.: US09951106B2Publication Date: 2018-04-24
- Inventor: Yongjun Guan , George Lewis , Anthony Devico , Mohammad Sajadi , Tongyun Liu , Marzena Pazgier
- Applicant: Yongjun Guan , George Lewis , Anthony Devico , Mohammad Sajadi , Tongyun Liu , Marzena Pazgier
- Applicant Address: US MD Baltimore
- Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
- Current Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
- Current Assignee Address: US MD Baltimore
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- International Application: PCT/US2013/073003 WO 20131204
- International Announcement: WO2014/089152 WO 20140612
- Main IPC: C07K14/005
- IPC: C07K14/005 ; C07K14/16 ; C07K16/10 ; A61K39/12 ; A61K39/21 ; A61K39/00
Abstract:
Fusion proteins comprising a portion of the HIV-1 Env protein (gp120 and gp140) and single-chain fragment V regions (ScFv) of an enhancing antibody that exhibits binding specificity for HIV-1 Env protein are disclosed that may serve in immunogenic formulations for vaccination against HIV-1 infection, as well as methods of generating an immune response using the fusion proteins.
Public/Granted literature
- US20150299268A1 HIV-1 ENV-BINDING ANTIBODIES, FUSION PROTEINS, AND METHODS OF USE Public/Granted day:2015-10-22
Information query
