Invention Grant
- Patent Title: Monoclonal antibodies against the DEC-205 receptor of chicken dendritic cells
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Application No.: US14898037Application Date: 2014-06-17
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Publication No.: US09951135B2Publication Date: 2018-04-24
- Inventor: Lourival Domingos Possani Postay , María Martha Pedraza Escalona , Gerardo Pavel Espino Solis , Alejandro Olvera Rodríguez , Héctor Miguel Cardoso Torres
- Applicant: UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO
- Applicant Address: MX Distrito Federal
- Assignee: UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO
- Current Assignee: UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO
- Current Assignee Address: MX Distrito Federal
- Agency: Studebaker & Brackett PC
- Priority: MXMX/a/2013/007474 20130626
- International Application: PCT/MX2014/000093 WO 20140617
- International Announcement: WO2014/209096 WO 20141231
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K39/145 ; C12N7/00 ; A61K47/68 ; A61K39/00
Abstract:
The invention relates to the production and the characterization of new murine monoclonal antibodies that recognize the domain CTDL-2 (SEQ ID NO: 1) of the cell receptor DEC-205 of dendritic cells in chickens (Gallus gallus), pigs, (Sus scrofa) and humans (Homo sapiens). The invention also relates to the capacity of the new antibodies to direct and modulate the immune response at different levels in chickens (Gallus gallus) and pigs (Sus scrofa), as well as recognizing the receptor DEC-205 in dentritic cells and cell lines in humans. In addition, the invention is used to quickly produce a specific humoral immune response against Hemaglutinina H5 of the H5N2-type avian flu virus.
Public/Granted literature
- US20160347841A1 NEW MONOCLONAL ANTIBODIES AGAINST THE RECEPTOR DEC-205 OF CHICKEN DENTRITIC CELLS Public/Granted day:2016-12-01
Information query
