Invention Grant
- Patent Title: Micrornas that silence tau expression
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Application No.: US14903164Application Date: 2014-07-11
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Publication No.: US09951330B2Publication Date: 2018-04-24
- Inventor: John Crary , Ismael Santa-Maria Perez
- Applicant: The Trustees of Columbia University in the City of New York
- Applicant Address: US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee Address: US NY New York
- Agency: Leason Ellis LLP
- International Application: PCT/US2014/046373 WO 20140711
- International Announcement: WO2015/006705 WO 20150115
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C12N15/113 ; C12Q1/68
Abstract:
This invention relates to the treatment and prevention of Alzheimer's disease (AD), tangle-predominant dementia (TPD) and other diseases associated with abnormal tau expression, e.g., tauopathies, using the 3′untranslated region (UTR) of the tau messenger RNA (mRNA) as a target, specifically using microRNAs that regulate the expression of tau. This invention is also in the field of screening for, identifying, and diagnosing such diseases. Specifically, this invention provides biomarkers for these diseases in the form of microRNAs.
Public/Granted literature
- US20170002348A1 MICRORNAS THAT SILENCE TAU EXPRESSION Public/Granted day:2017-01-05
Information query
