A method for operating a multi-core processor system, wherein different of a program are each executed simultaneously by a different respective processor core of the multi-core processor system includes inserting a breakpoint in a first of the threads for interrupting the first processor core and instead executing an exception handling routine. At least one processor core to be additionally interrupted is determined with the exception handling routine on the basis of an association matrix, and an inter-processor interrupt (IPI) is sent to the at least one processor core by the exception handling routine in order to interrupt the at least one processor core.