Invention Grant
- Patent Title: Crystal form of neptinib di-p-methylbenzenesulfonate, preparation method thereof, and pharmaceutical composition containing same
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Application No.: US15539070Application Date: 2015-12-22
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Publication No.: US09957237B2Publication Date: 2018-05-01
- Inventor: Tian Tang , Feng Jin , Yanqing Wang , Jing Wu , Xiarou Liu , Jing'an Yang , Hanlin Feng , Lin Yu
- Applicant: SHENZHEN NEPTUNUS PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD.
- Applicant Address: CN Shenzhen
- Assignee: SHENZHEN NEPTUNUS PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD.
- Current Assignee: SHENZHEN NEPTUNUS PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD.
- Current Assignee Address: CN Shenzhen
- Agency: Greer, Burns & Crain, Ltd.
- Priority: CN201410822395 20141225
- International Application: PCT/CN2015/098239 WO 20151222
- International Announcement: WO2016/101867 WO 20160630
- Main IPC: A61K31/517
- IPC: A61K31/517 ; C07D239/94 ; C07C309/30

Abstract:
Provided is a composition of N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(ethoxy)-6-quinazolinyl]-4-(dimethylamino)-2-butenamide p-toluene sulfonate 1.5 hydrate α-polymorph. The α-polymorph has a stable form, a defined melting point, a good chemical stability, and a good endurance to high temperature and light irradiation, and is suitable for pharmaceutical use.
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