Invention Grant
- Patent Title: Saturated nitrogen and N-acylated heterocycles potentiating the activity of an active antibiotic against Mycobacteria
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Application No.: US14653669Application Date: 2013-12-20
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Publication No.: US09957249B2Publication Date: 2018-05-01
- Inventor: Nicolas Willand , Benoit Deprez , Alain Baulard , Priscille Brodin , Marion Flipo , Lucie Maingot
- Applicant: Universite de Droit et de la Sante de Lille 2
- Applicant Address: FR Lille
- Assignee: UNIVERSITE DE DROIT ET DE LA SANTE DE LILLE 2
- Current Assignee: UNIVERSITE DE DROIT ET DE LA SANTE DE LILLE 2
- Current Assignee Address: FR Lille
- Agency: Medler Ferro Woodhouse & Mills PLLC
- Agent Cynthia M. Bouchez
- Priority: FR1203548 20121221
- International Application: PCT/EP2013/077732 WO 20131220
- International Announcement: WO2014/096378 WO 20140626
- Main IPC: C07D401/04
- IPC: C07D401/04 ; C07D295/185 ; C07D211/16 ; C07D211/18 ; C07D211/22 ; C07D207/08 ; A61K31/40 ; A61K31/451 ; A61K31/4545 ; A61K31/495 ; A61K45/06

Abstract:
The present invention concerns a compound of general formula (I): in which n=0 or 1, R1 represents an optionally substituted alkyl chain, in particular substituted alkyl chain, in particular substituted with fluorine, X is chosen from N and CH, and R2 is chosen from optionally substituted phenyl and benzyl, wherein the heterocycles having 6 vertices comprise one, two or three nitrogen atoms. The present invention also concerns the use of this compound as a medicament, in particular in the treatment of bacterial and mycobacterial infections such as tuberculosis in combination with an antibiotic that is active against bacteria and/or mycobacteria, said compound potentiating the activity of said antibiotic.
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