![5-substituted 7- [4-(2-pyridyl)phenylmethylamino] -3-isopropylpyrazolo4,3-D]pyrimidine derivatives, use thereof as medicaments, and pharmaceutical compositions](/docs/US/2018-05-01/US09957273B2/abs.jpg.600x600.jpg)
- Patent Title: 5-substituted 7- [4-(2-pyridyl)phenylmethylamino] -3-isopropylpyrazolo4,3-D]pyrimidine derivatives, use thereof as medicaments, and pharmaceutical compositions
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Application No.: US15558151Application Date: 2015-10-02
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Publication No.: US09957273B2Publication Date: 2018-05-01
- Inventor: Libor Havlicek , Antonin Sturc , Vladimir Krystof , Radek Jorda , Tomas Pospisil , Stefan Zahler , Angelika Vollmar , Miroslav Strnad
- Applicant: USTAV EXPERIMENTALNI BOTANIKY AV CR, V.V.I.
- Applicant Address: CZ Prague
- Assignee: USTAV EXPERIMENTALNI BOTANIKY AV CR, V.V.I.
- Current Assignee: USTAV EXPERIMENTALNI BOTANIKY AV CR, V.V.I.
- Current Assignee Address: CZ Prague
- Agency: Notaro, Michalos & Zaccaria P.C.
- Priority: CZ2015-324 20150514
- International Application: PCT/CZ2015/050006 WO 20151002
- International Announcement: WO2016/180380 WO 20161117
- Main IPC: C07D487/04
- IPC: C07D487/04
![5-substituted 7- [4-(2-pyridyl)phenylmethylamino] -3-isopropylpyrazolo4,3-D]pyrimidine derivatives, use thereof as medicaments, and pharmaceutical compositions](/abs-image/US/2018/05/01/US09957273B2/abs.jpg.150x150.jpg)
Abstract:
5-substituted-7-[4-(2-pyridyl)phenylmethylamino]-3-isopropylpyrazolo[4,3-d]pyrimidines are potent inhibitors of protein kinases, especially cyclin-dependent kinases such as CDK2 and CDK5, and display antileukemic, pro-apoptotic, antiangiogenic and anticancer activities. The invention also relates to processes for their preparation, to pharmaceutical compositions and to their use as medicaments, particularly in the treatment of disorders involving cell proliferation, apoptosis, angiogenesis and inflammation, such as leukemia and metastatic solid cancer.
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