Invention Grant
- Patent Title: Fluorescent probe for imaging lymph nodes
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Application No.: US15010612Application Date: 2016-01-29
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Publication No.: US09957392B2Publication Date: 2018-05-01
- Inventor: Hideki Hayashi , Masanori Fujinami , Taro Toyota , Yutaka Tamura , Akira Aoki , Yutaka Muraki , Kazuki Onoue
- Applicant: Eisai R&D Management Co., Ltd.
- Applicant Address: JP Tokyo
- Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- Priority: JP2010-124252 20100531
- Main IPC: C09B23/08
- IPC: C09B23/08 ; A61K49/00 ; C07D209/60 ; A61K9/127
Abstract:
Disclosed is a near-infrared fluorescent imaging agent comprising an indocyanine-based fluorescent dye and a liposome. The near-infrared fluorescent imaging agent of the present invention demonstrates high fluorescence intensity and a long anchoring time in sentinel lymph nodes, thereby making it useful for detecting sentinel lymph nodes in sentinel lymph node navigation surgery. Also disclosed is an indocyanine green derivative that is particularly suitable for use in the near-infrared fluorescent imaging agent of the present invention.
Public/Granted literature
- US20160222211A1 Fluorescent Probe for Imaging Lymph Nodes Public/Granted day:2016-08-04
Information query
