Invention Grant
- Patent Title: Attenuation of human respiratory syncytial virus by genome scale codon-pair deoptimization
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Application No.: US14766620Application Date: 2014-02-07
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Publication No.: US09957486B2Publication Date: 2018-05-01
- Inventor: Peter L. Collins , Cyril Le Nouën , Linda G. Brock , Ursula J. Buchholz , Joshua Marc DiNapoli , Steffen Mueller , Eckard Wimmer
- Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , The Research Foundation for the State University of New York
- Applicant Address: US DC Washington US NY Albany
- Assignee: The United States of America, as represented by the Secretary, Dept. of Health and Human Services,The Research Foundation For the State University of New York
- Current Assignee: The United States of America, as represented by the Secretary, Dept. of Health and Human Services,The Research Foundation For the State University of New York
- Current Assignee Address: US DC Washington US NY Albany
- Agency: Sheridan Ross P.C.
- International Application: PCT/US2014/015274 WO 20140207
- International Announcement: WO2014/124238 WO 20140814
- Main IPC: C12N7/00
- IPC: C12N7/00 ; A61K39/155 ; C07K14/005 ; A61K39/00
Abstract:
Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.
Public/Granted literature
- US20150368622A1 ATTENUATION OF HUMAN RESPIRATORY SYNCYTIAL VIRUS BY GENOME SCALE CODON-PAIR DEOPTIMIZATION Public/Granted day:2015-12-24
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