Invention Grant
- Patent Title: Crystal structure of human four-phosphate adaptor protein 2 glycolipid transfer protein like domain
-
Application No.: US15327583Application Date: 2015-07-23
-
Publication No.: US09957494B2Publication Date: 2018-05-01
- Inventor: Muthuraman Meiyappan , Maria A. DeMatteis
- Applicant: Shire Human Genetic Therapies, Inc. , Fondazione Telethon
- Applicant Address: US MA Lexington IT Roma
- Assignee: SHIRE HUMAN GENETIC THERAPIES, INC.,FONDAZIONE TELETHON
- Current Assignee: SHIRE HUMAN GENETIC THERAPIES, INC.,FONDAZIONE TELETHON
- Current Assignee Address: US MA Lexington IT Roma
- Agency: Choate, Hall & Stewart LLP
- Agent Brian E. Reese
- International Application: PCT/US2015/041683 WO 20150723
- International Announcement: WO2016/014758 WO 20160128
- Main IPC: C12N9/36
- IPC: C12N9/36 ; G01N33/68 ; G06F19/12 ; G06F19/16
Abstract:
In some embodiments, the present invention provides method of identifying compounds that bind to phosphoinositol 4-phosphate adaptor protein-2 (FAPP2), including the steps of computationally identifying a compound that binds to FAPP2 using the atomic coordinates of at least the amino acids which make up the substrate binding pocket of FAPP2. Also provided are methods of designing, selecting and/or optimizing a compound that binds to FAPP2.
Public/Granted literature
- US20170349889A1 CRYSTAL STRUCTURE OF HUMAN FOUR-PHOSPHATE ADAPTOR PROTEIN 2 GLYCOLIPID TRANSFER PROTEIN LIKE DOMAIN Public/Granted day:2017-12-07
Information query
IPC分类:
