Invention Grant
- Patent Title: Modulation of KCNH2 isoform expression by oligonucleotides as a therapeutic approach for long QT syndrome
-
Application No.: US15230718Application Date: 2016-08-08
-
Publication No.: US09957508B2Publication Date: 2018-05-01
- Inventor: Zhengfeng Zhou , Qiuming Gong , Matthew Stump
- Applicant: OREGON HEALTH & SCIENCE UNIVERSITY
- Applicant Address: US OR Portland
- Assignee: Oregon Health & Science University
- Current Assignee: Oregon Health & Science University
- Current Assignee Address: US OR Portland
- Agency: Lee & Hayes PLLC
- Main IPC: C12N15/113
- IPC: C12N15/113
Abstract:
Oligonucleotides with activity in preventing poly(A) adenylation at intron 9 of the KCNH2 gene, as well as pharmaceutical compositions comprising the oligonucleotides and methods of using the oligonucleotides to treat long QT syndrome in a subject are disclosed. The oligonucleotides include antisense sequences corresponding to sites termed DSE-1 and DSE-2 in intron 9.
Public/Granted literature
Information query
IPC分类:
