Invention Grant
- Patent Title: Production of propanols, alcohols, and polyols in consolidated bioprocessing organisms
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Application No.: US13391554Application Date: 2010-08-20
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Publication No.: US09957530B2Publication Date: 2018-05-01
- Inventor: John E. McBride , Vineet Rajgarhia , Arthur J. Shaw, IV , Shital A. Tripathi , Elena Brevnova , Nicky Caiazza , Johannes Pieter Van Dijken , Allan C. Froehlich , William Ryan Sillers , James H. Flatt
- Applicant: John E. McBride , Vineet Rajgarhia , Arthur J. Shaw, IV , Shital A. Tripathi , Elena Brevnova , Nicky Caiazza , Johannes Pieter Van Dijken , Allan C. Froehlich , William Ryan Sillers , James H. Flatt
- Applicant Address: HU Budapest
- Assignee: Lallemand Hungary Liquidity Management LLC
- Current Assignee: Lallemand Hungary Liquidity Management LLC
- Current Assignee Address: HU Budapest
- Agency: Nutter McClennen & Fish LLP
- International Application: PCT/US2010/046172 WO 20100820
- International Announcement: WO2011/022651 WO 20110224
- Main IPC: C12N1/00
- IPC: C12N1/00 ; C12N1/20 ; C12P7/04 ; C12P7/18 ; C12Q1/00 ; C12Q1/68 ; C07H21/04 ; C12P7/36

Abstract:
The present invention provides for novel metabolic pathways leading to propanol, alcohol or polyol formation in a consolidated bioprocessing system (CBP), where lignocellulosic biomass is efficiently converted to such products. More specifically, the invention provides for a recombinant microorganism, where the microorganism expresses one or more native and/or heterologous enzymes; where the one or more enzymes function in one or more engineered metabolic pathways to achieve: (1) conversion of a carbohydrate source to 1,2-propanediol, isopropropanol, ethanol and/or glycerol; (2) conversion of a carbohydrate source to n-propanol and isopropanol; (3) conversion of a carbohydrate source to isopropanol and methanol; or (4) conversion of a carbohydrate source to propanediol and acetone; wherein the one or more native and/or heterologous enzymes is activated, upregulated or downregulated.
Public/Granted literature
- US20120322078A1 Production of Propanols, Alcohols, and Polyols in Consolidated Bioprocessing Organisms Public/Granted day:2012-12-20
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