An active cooler having an insulated five sided box having an inner chamber, the box has an openable lid hingedly attached to the upper edge of the box, a temperature sensor in the inner chamber for detecting temperature readings of the inner chamber when the lid is closed, a peltier cooling element operably engaged to the inner chamber to remove heat, a voltage regulator operably connected to the sensor to change the cooling element in response to temperature readings from the sensor, and a wireless transmitter connected to the temperature sensor for transmission of temperature readings and detection of pre-determined temperatures. The cooler may also have a program that is operated by an onboard computer to generate temperature and time related data, transmit the data via cell phone, internet, or local area and interact with hand held devices via specialized application software.