Embodiments of the invention provide a method comprising creating a structural description for at least one neurosynaptic core circuit. Each core circuit comprises an interconnect network including plural electronic synapses for interconnecting one or more electronic neurons with one or more electronic axons. The structural description defines a desired neuronal activity for the core circuits. The desired neuronal activity is simulated by programming the core circuits with the structural description. The structural description controls routing of neuronal firing events for the core circuits.