The present invention provides a drive method of a liquid crystal display panel and a drive system, in which a sequence controller (3) comprises a counter (31), a TFT activation voltage calculation module (32) and an I2C instruction module (33), and the counter (31) adds 1 as outputting the display data of each row, and as adding to i×M/N, the TFT activation voltage calculation module (32) operates to obtain the target TFT activation voltage of the i+1th gate drive IC (GD(i+1)) and transmits the same to the I2C instruction module (33), and the I2C instruction module (33) controls the PWM IC (2) correspondingly output the corresponding target TFT activation voltage to the i+1th gate drive IC (GD(i+1)), which can adjust the TFT activation voltage in real time so that the TFT activation voltages, which the respective gate drive ICs actually receive are consistent.