The various embodiments set forth an active noise cancellation system that includes a source separation algorithm. The source separation algorithm enables the identification of acoustic inputs from a particular sound source based on a reference signal generated with one or more microphones. Consequently, the identified acoustic inputs can be cancelled or damped in a targeted listening location via an acoustic correction signal, where the acoustic correction signal is generated based on a sound source separated from the reference signal. Advantageously, the reference signal can be generated with a microphone, even though such a reference signal may include a combination of multiple acoustic inputs. Thus, noise sources that cannot be individually measured, for example with an accelerometer mounted to a vibrating structure, can still be identified and actively cancelled.