The present invention discloses a structure of pixel arrangement and a display device. The structure of pixel arrangement includes a first sub-pixel, and second sub-pixels and third sub-pixels that are provided surrounding the first sub-pixel, the first sub-pixel, portions of the second sub-pixels and portions of the third sub-pixels constituting a virtual rhombus, wherein a center of the first sub-pixel coincides with a center of the virtual rhombus; a center of the second sub-pixel coincides with a first vertex of the virtual rhombus; and a center of the third sub-pixel coincides with a second vertex of the virtual rhombus. Compared with the prior art, the number of sub-pixels required to achieve high resolution display in the present invention is smaller, so that the number of the sub-pixels is decreased.