Method and system for Single Event Latchup (SEL) current surge mitigation involves monitoring data signals for a protected device and deriving from them a detected signature comprised of one or more detected signature vector components. The detected signature vector components are compared to previously stored signature vector components. Based on the comparing, the system selectively differentiates between the occurrence of standard power surges associated with normal operation of the protected device, and a non-standard current surge which requires cycling power of the protected device for continued proper functioning of the protected device.