Methods and systems for reducing leaked downlink interference signals in a remote unit uplink path(s) in a distributed antenna system (DAS) are provided. In a remote antenna unit (RAU) disclosed herein, a downlink interference signal may be leaked from a downlink path to an uplink path in the RAU. In this regard, an adjustment circuit is provided in the downlink path of the RAU to suppress the downlink interference signal. A control system is provided in the DAS to monitor the leaked downlink interference signal and control the adjustment circuit in the RAU to minimize the leaked downlink interference signal in the uplink path. By providing the adjustment circuit in the RAU and the control system in the DAS to minimize the leaked downlink interference signal in the uplink path, it is possible to reduce interferences between downlink and uplink communications signals without increasing costs of the RAU.