Embodiments of the present invention provide techniques for managing interference across multiple transceivers in an access point in a network environment. A wireless networking system can include various access points. These access points may each include multiple transceivers. However, with multiple transceivers in close proximity, signals transmitted by one transceiver may interfere with another transceiver through crosstalk, adjacent channel interference, or other form of interference. Each access point may include an interference manager which can use an interference model to modify a signal transmitted by one transceiver to be used to cancel corresponding interference caused in a second transceiver. Interference can be modeled prior to deployment and/or at deployment using a series of test signals transmitted by one transceiver while the corresponding interference is monitored on a second transceiver. The interference model can be used to transform subsequent signals and used to filter interference from the second transceiver.