Invention Grant
- Patent Title: Methods related to TIM 3, a TH1-specific cell surface molecule, for activating antigen presenting cells
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Application No.: US14464455Application Date: 2014-08-20
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Publication No.: US09962440B2Publication Date: 2018-05-08
- Inventor: Vijay K. Kuchroo , Sumone Chakravarti , Catherine A. Sabatos-Peyton , Gordon J. Freeman
- Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , DANA-FARBER CANCER INSTITUTE, INC.
- Applicant Address: US MA Boston US MA Boston
- Assignee: The Brigham and Women's Hospital, Inc.,Dana-Farber Cancer Institute, Inc.
- Current Assignee: The Brigham and Women's Hospital, Inc.,Dana-Farber Cancer Institute, Inc.
- Current Assignee Address: US MA Boston US MA Boston
- Agency: Nixon Peabody LLP
- Agent Mark J. FitzGerald; Srividya Subramanian
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28 ; C07K16/18 ; A61K9/00 ; A61K45/06 ; A61K39/00
Abstract:
The present invention provides compositions and methods useful for promoting or reducing T-cell trafficking to a target tissue. Also provided are compositions and methods useful for promoting or inhibiting antigen-presenting cell (APC) activation. The invention is related to discovery of functional characteristics of TIM-3, a molecule that is preferentially expressed on the surface of Th1 cells. The methods are useful for treating disorders including cancer, infectious disease, allergy, asthma, and autoimmune disease.
Public/Granted literature
- US20150044229A1 METHODS RELATED TO TIM 3, A TH1-SPECIFIC CELL SURFACE MOLECULE, FOR ACTIVATING ANTIGEN PRESENTING CELLS Public/Granted day:2015-02-12
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