A hand-held device for combined light therapy and electrotherapy of a skin surface with acne, includes: a hand-held housing having an output port; at least one light source configured to emit light of different colors through the output port of the housing for light therapy of an acne lesion; and electrodes configured to apply a current across a center part of the output port for electrotherapy of the acne lesion, wherein the center part of the output port is located between the electrodes.