Invention Grant
- Patent Title: Use of citrate solution for affinity chromatographic purification of CRP using phosphocholine and derivatives thereof
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Application No.: US15526263Application Date: 2015-11-12
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Publication No.: US09962628B2Publication Date: 2018-05-08
- Inventor: Ahmed Sheriff , Birgit Vogt , Stephan Mattecka
- Applicant: Pentracor GmbH
- Applicant Address: DE Hennigsdorf
- Assignee: Pentracor GmbH
- Current Assignee: Pentracor GmbH
- Current Assignee Address: DE Hennigsdorf
- Agency: Knobbe, Martens, Olson & Bear, LLP
- Priority: EP14192831 20141112
- International Application: PCT/EP2015/076493 WO 20151112
- International Announcement: WO2016/075269 WO 20160519
- Main IPC: B01D15/38
- IPC: B01D15/38 ; B01D15/12 ; B01J20/286 ; B01J20/32 ; C07K14/47 ; B01J20/22 ; B01J20/281 ; B01J20/285
Abstract:
The invention relates to the use of a citrate solution for affinity-chromatographic removal of C-reactive protein (CRP) from biological fluids, wherein the CRP is affinity-chromatographically removed using (Ca2+-dependent) binding of CRP to a column material functionalized with ω-phosphonooxyalkyl ammonium groups and/or with ω-ammoniumalkoxy-hydroxy-phosphoryloxy groups.
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