Invention Grant
- Patent Title: Peptides that inhibit syndecan-1 activation of VLA-4 and IGF-1R
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Application No.: US15680423Application Date: 2017-08-18
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Publication No.: US09963498B2Publication Date: 2018-05-08
- Inventor: Alan C. Rapraeger , DeannaLee M. Beauvais , Oisun Jung
- Applicant: Wisconsin Alumni Research Foundation
- Applicant Address: US WI Madison
- Assignee: Wisconsin Alumni Research Foundation
- Current Assignee: Wisconsin Alumni Research Foundation
- Current Assignee Address: US WI Madison
- Agency: Boyle Fredrickson S.C.
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K14/705 ; A61K45/06 ; A61K38/17
Abstract:
A fusion peptides with sequences derived from the extracellular domain of syndecan-1 that inhibits VLA-4 and IGF-1R signaling are disclosed. The fusion peptides include an IGF-1R-binding segment having the amino acid sequence LPAGEGPKEGEAVVLPEVEPGLTAREQ (SEQ ID NO:1) and a VLA-4-binding segment having the amino acid sequence sequence DFTFETSGENTA (SEQ ID NO:2).
Public/Granted literature
- US20180086813A1 Peptides that Inhibit Syndecan-1 Activation of VLA-4 and IGF-1R Public/Granted day:2018-03-29
Information query
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