Techniques for facilitating an autonomous operation, such as an autonomous navigation, of an unmanned vehicle based on one or more fiducials. For example, image data of a fiducial may be generated with an optical sensor of the unmanned vehicle. The image data may be analyzed to determine a location of the fiducial. A location of the unmanned vehicle may be estimated from the location of the fiducial and the image. The autonomous navigation of the unmanned vehicle may be directed based on the estimated location.