The present application discloses a method and a device for operating a terminal having a touch screen, and the method includes steps of: starting to count a predetermined first time period when a predetermined condition is met; when an operation is performed by a user on a predetermined non-readily-mis-pressed region of the touch screen during the first time period, implementing the operation, otherwise implementing an operation performed by the user on a readily-mis-pressed region. The method and the device for operating a terminal having a touch screen provided by the disclosure solve the problem of error operations when a user holds the terminal by one hand and performs operations, thereby providing the user with conveniences.