An example method for interference suppression in full duplex cable network environments is provided and includes providing a baseband (BB) reference signal on a first pathway to a signal processor, converting the BB reference signal to a first radio frequency (RF) signal, transmitting the first RF signal on the first pathway, the first RF signal being reflected back on a second pathway, receiving a second RF signal on the second pathway, the second RF signal including interferences from the reflections, generating an RF reference signal based on signals on the first pathway, providing the RF reference signal to the signal processor, providing the second RF signal to the signal processor, and reducing, by the signal processor, interferences in the second RF signal from reflections of the first RF signal based on the BB reference signal and the RF reference signal.