Invention Grant
- Patent Title: Transgenic animals capable of being induced to delete senescent cells
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Application No.: US14792208Application Date: 2015-07-06
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Publication No.: US09968076B2Publication Date: 2018-05-15
- Inventor: James L. Kirkland , Tamar Tchkonia , Jan M. A. van Deursen , Darren J. Baker
- Applicant: Mayo Foundation for Medical Education and Research
- Applicant Address: US MN Rochester
- Assignee: Mayo Foundation for Medical Education and Research
- Current Assignee: Mayo Foundation for Medical Education and Research
- Current Assignee Address: US MN Rochester
- Agency: Fish & Richardson P.C.
- Main IPC: A01K67/027
- IPC: A01K67/027 ; C07K14/435 ; C12N15/62 ; A61K49/00
Abstract:
This document provides a transgenic mouse for studying the role of senescent cells in an age-related phenotype. A recombinant polypeptide is expressed in senescent cells under control of a p16INK4a promoter. The polypeptide can be triggered to directly induce cell death in senescent cells. As a result, progression of one or more age-related phenotypes is delayed in the mouse. An example is the INK-ATTAC mouse which also expresses a marker polypeptide in senescent cells.
Public/Granted literature
- US20150296755A1 TRANSGENIC ANIMALS CAPABLE OF BEING INDUCED TO DELETE SENESCENT CELLS Public/Granted day:2015-10-22
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