An embolic protection device includes an outer surface that is configured to form a substantially sealed relationship with a body lumen such that emboli are deflected and/or captured by the outer surface before such emboli can travel to other parts of the body. An inner surface of the embolic protection device includes a longitudinally extending lumen through which instrumentation may be inserted, facilitating passage of such instrumentation through the body lumen while minimizing risk to the patient from emboli.