Invention Grant
- Patent Title: Heterocycle analogs of CAI-1 as agonists of quorum sensing in vibrio
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Application No.: US14912207Application Date: 2014-08-19
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Publication No.: US09968587B2Publication Date: 2018-05-15
- Inventor: Bonnie L. Bassler , Lark J. Perez , Martin F. Semmelhack
- Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY
- Applicant Address: US NJ Princeton
- Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
- Current Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
- Current Assignee Address: US NJ Princeton
- Agency: Meagher Emanuel Laks Goldberg & Liao, LLP
- International Application: PCT/US2014/051648 WO 20140819
- International Announcement: WO2015/026796 WO 20150226
- Main IPC: A61K31/401
- IPC: A61K31/401 ; A01N43/36 ; C07D207/333 ; A61K45/06 ; A61K31/53
Abstract:
A structurally distinct and potent series of synthetic small molecule activators of Vibrio cholerae quorum sensing have been chemically synthesized. The small molecule activators reduce virulence in V. cholerae. Acyl pyrrole molecules displayed strong potency and stability, particularly 1-(1H-pyrrol-3-yl)decan-1-one.
Public/Granted literature
- US20160200678A1 HETEROCYCLE ANALOGS OF CAI-1 AS AGONISTS OF QUORUM SENSING IN VIBRIO Public/Granted day:2016-07-14
Information query
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