A pump cassette includes fluid lumen adapted for passage of an infusion fluid toward a patient. A rotary valve assembly can be actuated to regulate fluid flow through the fluid lumen and a frame is coupled to the fluid lumen and the valve assembly. The frame is adapted to be inserted into a seat of a pump device, wherein the frame provides a platen relative to the fluid lumen. The frame is configured to be inserted into the seat only when aligned in a predetermined orientation relative to the seat.