In a multi-piece solid golf ball having a two-layer core consisting of an inner layer and an outer layer, a cover, at least one intermediate layer between the core and the cover, and a paint film layer formed on the cover surface, each layer of the two-layer core is formed primarily of a rubber composition, the intermediate layer and the cover are each formed primarily of a resin material, the core has a hardness profile which satisfies specific conditions, and the sphere consisting of the core encased by the intermediate layer has a higher surface hardness than the ball. When used by mid- to high-level golfers, this ball achieves sufficient reduction in the spin rate on full shots with a driver, enabling the distance to be increased, and the spin performance on approach shots is excellent, enhancing the enjoyability of the game.