- Patent Title: Urea and amide derivatives of aminoalkylpiperazines and use thereof
-
Application No.: US15463051Application Date: 2017-03-20
-
Publication No.: US09969743B2Publication Date: 2018-05-15
- Inventor: Subramaniam Ananthan
- Applicant: Southern Research Institute
- Applicant Address: US AL Birmingham
- Assignee: SOUTHERN RESEARCH INSTITUTE
- Current Assignee: SOUTHERN RESEARCH INSTITUTE
- Current Assignee Address: US AL Birmingham
- Agency: Polsinelli PC
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D295/15 ; C07D239/42 ; C07D215/46 ; C07D213/14 ; C07D403/12 ; C07D401/12 ; C07D401/14 ; C07D215/38 ; C07D295/215 ; C07D471/04

Abstract:
Provided are compounds represented by the formula: In which: Y is an unbranched, saturated or unsaturated hydrocarbon chain with 2-5 hydrocarbon atoms R1=aryl R2=NR3R4 wherein R3 and R4 together form a heterocycle or R2=4-substitutedcyclohexyl, 1-substitutedpiperidine-4-yl or imidazo(1,2-a)azine-2-yl when Y is as defined above and R1 is a heterocycle other than benzothiophene pharmaceutically acceptable salts thereof, deuterated forms thereof, isomers thereof, solvates thereof, and mixtures thereof. The compounds can be used for treating a patient suffering from a condition that is capable of treatment with a partial agonist or antagonist of the dopamine D2/D3 receptors. The compounds are especially useful for patients suffering from schizophrenia, depressions, neurodegenerative diseases such as Parkinson's, dyskinesias, substance abuse and relapse to substance abuse and addiction to substances such as cocaine, methamphetamine, nicotine and alcohol, glaucoma, cognitive disorders, restless leg syndrome, attention deficit hyperactivity disorders, hyperprolactinemia, autism, motor disturbances such as akathisia, rigor, dystonias as well as various disorders of the urinary tract and other neurologic disorders. Also provided are processes for the preparation of compounds of the present disclosure.
Public/Granted literature
- US20170190711A1 UREA AND AMIDE DERIVATIVES OF AMINOALKYLPIPERAZINES AND USE THEREOF Public/Granted day:2017-07-06
Information query