Invention Grant
- Patent Title: Methods and compositions for treating and preventing disease associated with alpha-V beta-8 integrin
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Application No.: US14778997Application Date: 2014-04-01
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Publication No.: US09969804B2Publication Date: 2018-05-15
- Inventor: Dean Sheppard , Amha Atakilit , Neil Cowan Henderson
- Applicant: The Regents of the University of California
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Kilpatrick Townsend & Stockton LLP
- International Application: PCT/US2014/032550 WO 20140401
- International Announcement: WO2014/165524 WO 20141009
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C07K16/28
Abstract:
Antibodies (e.g., isolated antibodies) that specifically bind to human integrin β8 and inhibit adhesion of latency associated peptide (LAP) to αvβ8 are provided. In some embodiments, the antibody cross-reacts with mouse integrin β8. In some embodiments, the antibody blocks TGFJ3 activation. In some embodiments, the antibody antagonizes binding of LAP to αβ8 with an IC50 below 5 nM.
Public/Granted literature
- US20160046717A1 METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING DISEASE ASSOCIATED WITH ALPHA-V BETA-8 INTEGRIN Public/Granted day:2016-02-18
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